Tryptase CNV Test - Clinical

Elevated serum tryptase levels have been associated with a wide range of multi symptom complaints including:

  1. Cutaneous flushing, itching and severe allergic reactions
  2. Dysautonomia
  3. Functional gastrointestinal symptoms
  4. Chronic pain
  5. Connective tissue abnormalities

A recent NIH study1 found that inherited increases in serum tryptase levels correlated with duplications (and triplications) of the gene encoding α-tryptase (TPSAB1).

Based on the results of this study, Gene By Gene has developed a clinical assay to identify people with multiple copies of α-tryptase. The test is now available for the out-of-pocket cost of $169*. For more information or to order the test, please contact Gene By Gene at or (832)-761-9643.

*This test is not offered direct to consumer (DTC). It must be authorized by a qualified medical professional.

*This test is not currently available for New York State residents.


  1. Lyons et al. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nature Genetics volume 48, pages 1564–1569 (2016).

MD Only

Turnaround Time
6 weeks